Location:
Hongling Liu, Ph.D.
Associate Professor
School of Environment
Nanjing University
Tel：+86-25-8968-0356
Email: hlliu@hgbetting.com
ORCID: 0000-0003-1315-1687
Education
Ph.D. in School of Environment, Nanjing University, 2002~2007
B.S. in College of Hydrology and Water Resources, Hohai University, 1994~1998
Professional Experience
Associate Professor, School of Environment, Nanjing University, 2011~
Visiting scholar, University of Saskatchewan, 2013~2014
Lecturer, School of Environment, Nanjing University, 2007~2011
Engineer, Funing County Environmental Protection Bureau, Jiangsu Province, 1998~2002
Research Interests
Ecotoxicology of Environmental Pollutants
Ecological Risk Analysis of Chemicals
Research on Water Environment Quality Standards of Chemicals
Academic Service
Teaching
Undergraduate class teaching, Environmental monitoring experiment
Graduate class teaching, Eco-risk assessment of environmental pollutants
Selected Publications
First or corresponding author of SCI paper:
41） Xuehua Sun, Li Zhang, Hongling Liu*, Zunyao Wang, John P. Giesy. Ecotoxicological risk assessment of metal cocktails based on maximum cumulative ratio during multi-generational exposures, Water Research, 2021, 200, 117274.
40） Xuan Liu, Xianyi Xie, Hongling Liu*. Effects of Diethylstilbestrol on Zebrafish Gonad Development and Endocrine Disruption Mechanism, Biomolecules, 2021,11,941.
39） Jingwen Song, Zhiyuan Ma, Haoyue Kong, Hongling Liu*. A mechanistic effect modeling approach to the prioritization of hidden drivers in chemical cocktails, Sci Total Environ, 2020, 748, 142525.
38） Zhiyuan Ma, Hongling Liu*, Hongxia Yu. Triclosan affects Ca2+ regulatory module and musculature development in skeletal myocyte during early life stage of zebrafish (Danio rerio). Environ. Sci. Technol. 2019, 53(20): 11988-98.
37） Xianyi Xie, Yaru Jin, Zhiyuan Ma, Song Tang, Hui Peng, John P. Giesy, Hongling Liu*. Underlying Mechanisms of Reproductive Toxicity Caused by Multigenerational Exposure of 2, bromo-4, 6-dinitroaniline (BDNA) to Zebrafish (Danio rerio) at Environmental Relevant Levels. Aquatic Toxicol, 2019, 216, 105285.
36）Hongling Liu*, Laihao Shi, John P. Giesy, Hongxia Yu. Polychlorinated diphenyl sulfides can induce ROS and genotoxicity via the AhR-CYP1A1 pathway. Chemosphere, 2019, 223, 165-70.
35) Yuandan Ma, Yuqiong Tang, Hao Xu, Xiuying Zhang*, Hongling Liu*, Shanqian Wang, Wuting Zhang. Bulk/wet deposition of trace metals to rural, industrial, and urban areas in the Yangtze River Delta, China. Ecotoxicology and Environmental Safety, 2019,169, 185-91.
34）Xiaohui Zhang, Song Tang*, Mao Wang*, Weimin Sun, Yuwei Xie, Hui Peng, Aimin Zhong, Hongling Liu*, Xiaowei Zhang, Hongxia Yu, John P. Giesy, Markus Hecker. Acid mine drainage affects the diversity and metal resistance gene profile of sediment bacterial community along a river. Chemosphere, 2019, 217, 790-9.
33) Zhiyuan Ma, Hui Peng, Yaru Jin, Xianming Zhang, Xianyi Xie, Kang Jian, Hongling Liu*, Guanyong Su, Song Tang, Hongxia Yu. Multigenerational Effects and Demographic Responses of Zebrafish (Danio rerio) Exposed to Organo-Bromine Compounds. Environ. Sci. Technol. 2018, 52 (15), 8764-73.
32）Zhang L, Xu EGB, Li YB, Liu HL*, Vidal-Dorsch DE, Giesy JP. Ecological risks posed by ammonia nitrogen (AN) and un-ionized ammonia (NH3) in seven major river systems of China, Chemosphere, 2018, 202, 136-44.
31) Liu HL, Ma ZY, Zhang T, Yu NY, Su GY, Giesy JP, Yu HX*. Pharmacokinetics and effects of tetrabromobisphenol a (TBBPA) to early life stages of zebrafish (Danio rerio). Chemosphere, 2018, 190, 243-52.
30) Zhang L, Jin YR, Liu HL*, Shi LH, Doering JA, Tang S, Giesy JP. Yu HX. Integrated in Silico and in Vivo Approaches to Investigate Effects of BDE-99 Mediated by the Nuclear Receptors on Developing Zebrafish. Environ Toxic Chem, 2017, 9999, 1-8.
29) Li YB, Xu EGB, Liu W, Chen Y, Liu HL*, Li D, Liu ZT, Giesy JP, Yu HX. Spatial and temporal ecological risk assessment of unionized ammonia nitrogen in Tai Lake, China (2004-2015), Ecotox Environ Saf, 2017, 140, 249-55.
28) Wu Y, Su GY, Tang S, Liu W, Ma ZY, Zheng XM, Liu HL*, Yu HX*. The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish. Chemosphere, 2017, 168: 122-130.
27) Wu Y, Doering JA, Ma ZY, Tang S, Liu HL*, Zhang XW, Wang XX, Yu HX*. Identification of androgen receptor antagonists: in vitro investigation and classification methodology for flavonoid. Chemosphere, 2016, 158:72-79.
26) Ma ZY, Tang S, Su GY, Miao YQ, Liu HL*, Xie YW, Giesy J., Saunders D.M.V., Hecker M, Yu HX. Effects of tris (2-butoxyethyl) phosphate (TBOEP) on endocrine axes during development of early life stages of zebrafish (Danio rerio). Chemosphere, 2016,144:1920-1927
25) Chen Y, Yu SY, Tang S, Li YB, Liu HL*, Zhang XH, Su GY, Li B, Yu HX, Giesy J. Site-specific water quality criteria for aquatic ecosystems: A case study of pentachlorophenol for Tai Lake, China. Sci Total Environ, 2016, 541: 65-73.
24) Ma ZY, Yu YJ, Tang S, Liu HL*, Su GY, Xie YW, Giesy J, Hecker M, Yu HX. Differential modulation of expression of nuclear receptor mediated genes by tris (2-butoxyethyl) phosphate (TBOEP) on early life stages of zebrafish (Danio rerio). Aquatic Toxicol, 2015, 169:196-203.
23) Liu HL*, Tang S, Zheng XM, Zhu YT, Ma ZY, Liu CS, Hecker M, Saunders D, Giesy J, Zhang XW, Yu HX*. Bioaccumulation, biotransformation and toxicity of BDE-47, 6-OH-BDE-47 and 6-MeO-BDE-47 in early life-stages of zebrafish (Danio rerio). Environ Sci Technol, 2015, 49 (3): 1823-33.
22) Li YB, Han ZH, Zheng XM, Ma ZY, Liu HL*, Giesy JP, Xie YW, Yu HX. Comparison of waterborne and in ovo nanoinjection exposures to assess effects of PFOS on Zebrafish embryos. Environ Sci Pollut Res, 2015, 22: 2303-10.
21) Wen Q, Liu HL*, Zhu YT, Zheng XM, Su GY, Zhang XW, Yu HX*, Giesy JP, Lam MHW. Maternal transfer, distribution, and metabolism of BDE-47 and its related hydroxylated, methoxylated analogs in zebrafish (Danio rerio). Chemosphere, 2014, 120C: 31-6.
20) Shi R, Yang CH, Su RH, Jin JR, Chen Y, Liu HL*, Giesy JP, Yu HX. Weighted Species Sensitivity Distributions Method to Derive Site-Specific Quality Criteria for Copper in Tai Lake, China. Environ Sci Pollut Res, 2014, 21:12968-78.
19) Chen Y, Huang J, Xing LQ, Liu HL*, Giesy J P, Yu HX, Zhang XW. Effects of Multi-generational exposures of D. magna to Environmentally Relevant Concentrations of Pentachlorophenol. Environ Sci Pollut Res, 2014, 21: 234-43.
18) Xing LQ, Liu HL*, Zhang XW, Hecker M, Giesy JP, Yu HX. A comparison of statistical methods for deriving freshwater quality criteria for the protection of aquatic organisms. Environ Sci Pollut Res, 2014, 21: 159-67.
17) Zheng XM, Zhu YT, Liu CS, Liu HL*, Giesy JP, Hecker M, Lam MHW, Yu HX*. Accumulation and biotransformation of BDE-47 by zebrafish larvae and teratogenicity and expression of genes along the hypothalamus –pituitary -thyroid axis. Environ Sci Technol, 2012, 46(23): 12943-51.
16) Xing LQ, Liu HL*, Giesy JP, Yu HX*. pH-dependent aquatic criteria for 2,4-dichlorophenol, 2,4,6-trichlorophenol and pentachlorophenol. Sci Total Environ, 2012, 441C：125-31.
15) Xing LQ, Sun J, Liu HL*, Yu HX*. Combined toxicity of three chlorophenol 2,4-dichlorophenol, 2,4,6-trichlorophenol, and pentachlorophenol to Daphnia magna. J Environ Monit, 2012, 14(6), 1677-1683. (invited)
14) Zheng XM, Liu HL*, Shi W, Wei S, Giesy JP, Yu HX*. Effects of Perfluorinated Compounds on Development of Zebrafish Embryos. Environ Sci Pollut Res, 2012, 19：2498-505.
13) Wen Q, Liu HL, Su GY, Wei S, Feng JF, Yu HX*. Determination of Polybrominated Diphenyl Ethers and Their Derivates in Zebrafish Eggs. Chine J Anal Chem 2012, 40 (11): 1698-702.
12) Xing LQ, Liu HL, Giesy JP, Zhang XW, Yu HX*. Probabilistic ecological risk assessment for three chlorophenols in surface water of China. J Environ Sci, 2012, 24(2): 329-34.
11) Shi W, Zhang FX, Hu GJ, Hao YQ, Zhang XW, Liu HL*, Wei S, Wang XR, Giesy JP, Yu HX*. Thyroid hormone disrupting activities associated with phthalate esters in water sources from Yangtze River Delta. Environ Int, 2012, 42：117-23.
10) Liu HL, Hu W, Sun H, Shen OX, Wang XR, Lam MHW, Giesy JP, Zhang XW, Yu HX*. In vitro profiling of endocrine disrupting potency of 2,2',4,4'-tetrabromodiphenyl ether (BDE47) and related hydroxylated analogues (HO-PBDEs). Mar Pollut Bull, 2011, 63: 287-96.
9) Hu W, Liu HL*, Sun H, Shen OX, Wang XR, Lam MHW, Giesy JP, Zhang XW, Yu HX*. Endocrine effects of methoxylated brominated diphenyl ethers in three in vitro models. Mar Pollut Bull, 2011, 62：2356-61.
8) Shi W, Zhang FX, Zhang XW, Su GY, Wei S, Liu HL*, Cheng SP, Yu HX*. Identification of trace organic pollutants in freshwater sources in Eastern China and estimation of their associated human health risks. Ecotoxicology, 2011, 20(5): 1099-106.
7) Shi W, Wang XY, Hu GJ, Hao YQ, Zhang XW, Liu HL*, Wei S, Wang XR, Yu HX*. Bioanalytical and instrumental analysis of thyroid hormone disrupting compounds in water sources along the Yangtze River. Environ Pollut, 2011, 159: 441-8.
6) Zhang FX, Hu W, Yu HX, Sun H, Shen OX, Wang XR, Liu HL*, Lam M H W, Giesy JP, Zhang XW. Endocrine disruption effects of 2, 2', 4, 4', 6 -pentabromodiphenylether (BDE100) in reporter gene assay. J Environ Monit, 2011, 13 (4): 850-4.
5) Liu HL, Chen JT, Wan, FY, Wang ZY, Wang LS. Theoretical Study on the Thermodynamic Properties and Stability of Polybrominated Diphenyl Sulfide Catena. Acta Chimica Sinica, 2010, 68(6): 540-50.
4) Liu HL, Yu HX*, Giesy JP, Xu TL, Zhou Y. Response of antioxidant parameters to 3,3’-dimethyl-benzidine in goldfish (Carassius auratus) liver. Fresen Environ Bull, 2009, 18 (5a): 737-43.
3) Liu HL, Chen JN, Jiang J, Giesy JP, Yu HX*, Wang XR. Cytotoxicity of HC Orange NO.1 to L929 fibroblast cells. Environ Toxic Pharm, 2008, 26 (3): 309-14.
2) Liu HL, Yu Y, Kong FX, He LN, Yu HX*, Giesy JP, Wang XR. Effects of tetrabromobisphenol A on the green alga Chlorella pyrenoidosa. J Environ Sci Heal A, 2008, 43 (11): 1271-8.
1) Liu HL, Yu HX*, Giesy JP, Sun YY, Wang XR. Toxicity of HC Orange No.1 to Daphnia magna, Zebrafish (Brachydanio rerio) embryos and goldfish (Carassius auratus). Chemosphere, 2007, 66 (11): 2159-65.
Co-published：
26) Su GY, Saunders D, Yu YJ, Yu HX, Zhang XW, Liu HL, Giesy JP. Occurrence of additive brominated flame retardants in aquatic organisms from Tai Lake and Yangtze River in Eastern China, 2009-2012. Chemosphere, 2014, 114: 340-6.
25) Han ZH, Wang QW, Fu J, Chen HS, Zhao Y, Zhou BS, Gong ZY, Wei S, Li J, Liu HL, Zhang XW, Liu CS*, Yu HX. Multiple bio-analytical methods to reveal possible molecular mechanisms of developmental toxicity in zebrafish embryos/larvae exposed to tris(2-butoxyethyl) phosphate. Aquat Toxicol, 2014, 150: 175-81.
24) Li XL, Wang XX, Shi W, Liu HL, Yu HX*. Analysis of Ah receptor binding affinities of polybrominated diphenyl ethers via in silico molecular docking and 3D-QSAR. SAR QSAR in Environ Res, 2013, 24(1): 75-87.
23) Li XL, Ye L, Shi W, Liu HL, Liu CS, Qian XP, Zhu YL, Yu HX*. In silico study on hydroxylated polychlorinated biphenyls as androgen receptor antagonists. Ecotoxicol Environ Saf, 2013, 92: 258-64.
22) Li X, Ye L, Wang X, Shi W, Liu H, Qian X, Zhu Y, Yu H. In silico investigations of anti-androgen activity of polychlorinated biphenyls. Chemosphere, 2013, 2(7): 795-802.
21) Fu J, Han J, Zhou B, Gong Z, Santos EM, Huo X, Zheng W, Liu H, Yu H, Liu C. Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) reveal possible molecular mechanisms of developmental toxicity. Environ Sci Technol, 2013, 47(18): 10574-82.
20) Su GY, Liu XH, Gao ZS, Xian QM, Feng JF, Zhang XW, Wei S, Liu HL, Yu HX*. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in fish & meat in diets of residents of Nanjing, China. Environ Int, 2012, 42: 138-43.
19) Su GY, Zhang XW*, Liu HL, Giesy JP, Lam M, Lam P, Siddiqui M, Musarrat J, Al-Khedhairy A, Yu HX*. Toxicogenomic Mechanisms of 6-HO-BDE-47, 6-MeO-BDE-47 and BDE-47 in E. Coli. Environ Sci Technol, 2012, 46(2): 1185-91.
18) Su G, Xia J, Liu H, Lam MH, Yu H, Giesy JP, Zhang X. Dioxin-like potency of HO- and MeO- analogues of PBDEs' the potential risk through consumption of fish from eastern China. Environ Sci Technol. 2012, 46(19): 10781-8.
17) Shi W, Hu X, Zhang F, Hu G, Hao Y, Zhang X, Liu H, Wei S, Wang X, Giesy JP, Yu H. Occurrence of thyroid hormone activities in drinking water from eastern China: contributions of phthalate esters. Environ Sci Technol. 2012 46(3):1811-8.
16) Liu CS, Wang QW, Liang K, Liu JF, Zhou SB, Zhang XW, Liu HL, Giesy JP, Yu HX. Effects of tris (1, 3-dichloro-2-propyl) phosphate and triphenyl phosphate on receptor-associated mRNA expression in zebrafish embryos/larvae. Aquat Toxicol, 2012, 128-129, 147-57.
15) Liu C, Yan W, Zhou B, Guo Y, Liu H, Yu H, Giesy JP, Wang J, Li G, Zhang X. Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos. Aquat Toxicol. 2012, 118-119:108-15.
14) Li XL, Ye L, Wang XX, Wang XZ, Liu HL, Zhu YL, Yu HX*. Combined 3D-QSAR, molecular docking and molecular dynamics study on thyroid hormone activity of hydroxylated polybrominated diphenyl ethers to thyroid receptors β. Toxicol Appl Pharmacol, 2012, 265: 300-7.
13) Li XL, Ye L, Wang XX, Wang XZ, Liu HL, Qian XP, Zhu YL, Yu HX*. Molecular docking, molecular dynamics simulation, and structure-based 3D-QSAR studies on estrogenic activity of hydroxylated polychlorinated biphenyls. Sci Total Environ, 2012, 441: 230-8.
12) Li XL, Wang ZY, Liu HL, Yu HX*. Quantitative structure–activity relationship for prediction of the toxicity of phenols on Photobacterium phosphoreum. Bull Environ Contam Toxicol, 2012, 89: 27-31.
11) Yang WH, Wei S, Liu HL, Yu HX*. Insights into the structural and conformational requirements of polybrominated diphenyl ethers and metabolites as potential estrogens based on molecular docking. Chemosphere, 2011, 84(3): 328-35.
10) Zhang X, Wiseman S, Yu H, Liu H, Giesy JP, Hecker M. Assessing the toxicity of naphthenic acids using a microbial genome wide live cell reporter array system. Environ Sci Technol. 2011 45(5): 1984-91.
9) Yang WH, Wang ZY, Liu HL, Yu HX*. Exploring the binding features of polybrominated diphenyl ethers as estrogen receptor antagonists: docking studies. SAR QSAR Environ Res, 2010, 21(3): 351-67.
8) Yang WH, Liu XH, Liu HL, Wu Y, Giesy JP, Yu HX*. Molecular Docking and Comparative Molecular Similarity Indices Analysis Study of Estrogenicity of Polybrominated Diphenyl Ethers and Their Analogues. Environ Toxicol Chem, 2010, (29): 660-8.
7) Wang XY, Shi W, Wu J, Hu GJ, Hao YQ, Liu HL, Han XD, Yu HX*. The reproductive toxicity of organic extracts from petrochemical plant effluents discharged to Yangtze River, China. J Environ Sci, 2010, 22(2): 297-303.
6) Li XD, Xing QM, Liu HL, Hua RM, Xu SS, Chen HY, Yu HX*. Simultaneous Determination of Three Sulfonamides Residues in Vegetable by High Performance Liquid Chromatographic Method with Fluorimetric Detection. Chine J Anal Chem, 2010, 38(3): 429-33.
5) Yu YJ, Liu HL, Dai XL, Cai HX, Li CY, Yu HX*. Trace analysis of phenols and chlorophenols in water by in-situ derivatization headspace solid-phase microextraction coupled with GC/MS. Chine J Anal Chem, 2010, 38 (9): 1243-8.
4) Su GY, Wen Q, Wei S, Feng JF, Liu HL, Yu HX*, Determination of Polybrominated Diphenyl Ethers and Their Metabolites in Cell Culture Using Gas Chromatography/Tandem Mass Spectrometry. Chinese Journal of Analytical Chemistry, 2010, 361-6.
3) Shi W, Wang XY, Hu W, Sun H, Shen QX, Liu HL, Wang XR, Giesy JP, Cheng SP, Yu HX*. Endocrine-disrupting equivalents in industrial effluents discharged into Yangtze River Compounds. Ecotoxicology, 2009, 18: 685-92
2) Chen JT, Liu HL, Wang FY, Yu HX, Li DL. QSPR Study on the Boiling Points of Some Oxygen and Sulfur-containing Organic Compounds. Chine J Struct Chem, 2009, 18(12): 1561-8.
1) Sun YY, Yu HX*, Zhang JF, Yin Y, Shen H, Liu HL, Wang XR. Bioaccumulation and antioxidant responses in goldfish Carassius auratus under HC Orange No. 1 exposure. Ecotoxicol Environ Saf, 2006, 63: 430-7.
（//www.researchgate.net/profile/Hongling_Liu）
Patents
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